ncreasing Prevalence of Multiple Drug Resistant Non-Fermenting Gram Negative Bacteria as Nosocomial Pathogens

Neha Chauhan1*, Juhi Chaudhary2, Chhaya Singh3, Anju Rani4, Divya Chauhan5

1*Department of Microbiology, School of Paramedical & Allied Health sciences, Shri Guru Ram Rai University, Dehradun- 248001, Uttarakhand, India.

2Department of Microbiology, School of Basic and Applied Sciences, Shri Guru Ram Rai University, Dehradun- 248001, Uttarakhand, India.

3Department of Botany, Govt. PG College, Thalisain, Pauri Garhwal 246285, Uttarakhand, India.

4Department of Botany, Keral Verma Subharti College of Science, Swami Vivekanand Subharti University, Meerut 250005, Uttar Pradesh, India.

5Department of Radio and Imaging Technology, School of Paramedical & Allied Health sciences, Shri Guru Ram Rai University Patel Nagar, Dehradun- 248001, Uttarakhand, India.

*Corresponding author email: chauhanneha7777@gmail.com.

Abstract

Antibiotic resistance is one of the most important public health challenges in the current situation. Antibiotic resistance was once only associated with nosocomial illnesses, but it is now a widespread occurrence. This syndrome could be caused by a number of circumstances, including extensive development, overuse of antibiotics, overuse of broad-spectrum medications, and a lack of target-oriented antimicrobial treatments. Due to the limited number of effective antimicrobial medicines available today, drug-resistant bacteria are becoming more common. By 2050, it’s predicted that there won’t be any effective antibiotics on the market to treat these lethal resistant infections if new, innovative medications aren’t found or developed. Because of this, we need to develop new, innovative medications or find other approaches or replacements to treat these multidrug-resistant microbes (MDR). The evolution of the most prevalent multidrug-resistant bacteria is the main topic of this paper, which also covers how these bacteria become multidrug resistant by evading the effects of targeted antibiotics. We also go through a few other ways to stop them from getting infected.

Keywords: Nosocomial infections, Novel drugs, MDR, antimicrobial agents